No unique dose adjustment recommended when tofacitinib coadministered with potent CYP2C19 inhibitors; lower tofacitinib dose if coadministered with the two reasonable CYP3A4 and potent CYP2C19 inhibitors .crizotinib raises levels of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch. Dose reduction may very well b
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